Topics in Companion Animal Medicine
Volume 24, Issue 4 , Pages 189-198 , November 2009

Infectious Hepatopathies in Dogs and Cats

  • Shawn Kearns, DVM, DACVIM (Internal Medicine)

      Affiliations

    • Corresponding Author InformationAddress reprint requests to: Shawn Kearns, DVM, DACVIM, Angell Animal Medical Center—Boston, 350 South Huntington Ave, Boston, MA 02130

References 

  1. Scherk MA, Center SA. Toxic, metabolic, infectious, and neoplastic liver diseases. In:  Ettinger SJ,  Feldman EC editor. Textbook of Veterinary Internal Medicine. (ed 6). St Louis: Elsevier; 2005;p. 1464–1478
  2. Center SA. Hepatobiliary infections. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 912–918
  3. Howe LM, Boothe DM, Boothe HW. Detection of portal and systemic bacteremia in dogs with severe induced hepatic disease and multiple portosystemic shunts. Am J Vet Res. 1999;60:181–185
  4. Center SA. Diseases of the gallbladder and biliary tree. In:  Guilford G,  Center SA,  Strombeck D, et al. editor. Strombeck's Small Animal Gastroenterology. (ed 3). Philadelphia: WB Saunders; 1996;p. 860–888
  5. Center SA, Rowland PH. Cholangitis/cholangiohepatitis complex in the cat. In: Proceedings of the 12th American College of Veterinary Internal Medicine Forum. 1994;p. 766–771San Francisco, California,.
  6. Wagner KA, Hartmann FA, Trepanier LA. Bacterial culture results from liver, gallbladder, or bile in 248 dogs and cats evaluated for hepatobiliary disease: 1998-2003. J Vet Intern Med. 2007;21:417–424
  7. Sergeeff JS, Armstrong PJ, Bunch SE. Hepatic abscesses in cats: 14 cases (1985-2002). J Vet Intern Med. 2004;18:295–300
  8. Schwarz LA, Penninck DG, Leveille-Webste C. Hepatic abscesses in 13 dogs: a review of the ultrasonographic findings, clinical data and therapeutic options. Vet Radiol Ultrasound. 1998;39:357–365
  9. Downs MO, Miller MA, Cross AR, et al. Liver lobe torsion and liver abscess in a dog. J Am Vet Med Assoc. 1998;212:678–680
  10. Grooters AM, Sherding RG, Biller DS, et al. Hepatic abscesses associated with diabetes mellitus in two dogs. J Vet Intern Med. 1994;8:203–206
  11. Singh M, Krockenberger M, Martin P, et al. Hepatocellular carcinoma with secondary abscessation in a cat. Aust Vet J. 2005;83:736–739
  12. Grooters AM, Sherding RG, Johnson SE. Hepatic abscesses in dogs. Compend Contin Educ Pract Vet. 1995;17:833–840
  13. Farrar ET, Washabau RJ, Saunders HM. Hepatic abscesses in dogs: 14 cases (1982-1994). J Am Vet Med Assoc. 1996;208:243–247
  14. Green CE, Sykes JE, Brown CA, et al. Leptospirosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 402–415
  15. Bishop L, Strandberg JD, Adams RJ, et al. Chronic active hepatitis in dogs associated with leptospires. Am J Vet Res. 1979;40:839–844
  16. Adamus C, Buggin-Daubié M. Chronic hepatitis associated with leptospiral infection in vaccinated beagles. J Comp Pathol. 1997;117:311–328
  17. Harkin KR, Roshto YM, Sullivan JT. Clinical application of a polymerase chain reaction assay for diagnosis of leptospirosis in dogs. J Am Vet Med Assoc. 2003;222:1224–1229
  18. Gillespie TN, Washabau RJ, Goldschmidt MH, et al. Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease. J Am Vet Med Assoc. 2003;222:47–51
  19. Kitchell BE, Fan TM, Kordick D, et al. Peliosis hepatis in a dog infected with Bartonella henselae. J Am Vet Med Assoc. 2000;216:519–523
  20. Fox JG, Drolet R, Higgins R, et al. Helicobacter canis isolated from a dog liver with multifocal necrotizing hepatitis. J Clin Microbiol. 1996;34:2479–2482
  21. Greiter-Wilke A, Scanziani E, Soldati S, et al. Association of Helicobacter with cholangiohepatitis in cats. J Vet Intern Med. 2006;20:822–827
  22. Gliatto JM, Rae JF, McDonough PL, et al. Feline tularemia on Nantucket Island, Massachusetts. J Vet Diagn Invest. 1994;6:102–105
  23. Rhyan JC, Gahagan T, Fales WH. Tularemia in a cat. J Vet Diagn Invest. 1990;2:239–241
  24. Baldwin CJ, Panciera RJ, Morton RJ, et al. Acute tularemia in three domestic cats. J Am Vet Med Assoc. 1991;199:1602–1605
  25. Boschert KR, Allison N, Allen TL, et al. Bacillus piliformis infection in an adult dog. J Am Vet Med Assoc. 1988;192:791–792
  26. Jones BR, Johnstone AC, Hancock WS. Tyzzer's disease in kittens with familial primary hyperlipoproteinaemia. J Small Anim Pract. 1985;26:411–419
  27. Meads EB, Maxie MG, Baker B. Tyzzer's disease in a puppy. Can Vet J. 1984;25:134
  28. Myerslough N. Tyzzer's disease in puppies. Vet Rec. 1988;122:238
  29. Green CE, DeBey DM. Tularemia. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 446–450
  30. Dillon R. The liver in systemic disease. An innocent bystander. 1985;15:97–117
  31. Poonacha KB, Smith HL. Naturally occurring Tyzzer's disease as a complication of distemper and mycotic pneumonia in a dog. J Am Vet Med Assoc. 1976;169:419–420
  32. Qureshi SR, Carlton WW, Olander HJ. Tyzzer's disease in a dog. J Am Vet Med Assoc. 1976;168:602–604
  33. Schneck G. Tyzzer's disease in an adult cat. Vet Med Small Anim Clin. 1975;70:155–156
  34. Kovatch RM, Zebarth G. Naturally occurring Tyzzer's disease in a cat. J Am Vet Med Assoc. 1973;162:136–138
  35. Young JK, Baker DC, Burney DP. Naturally occurring Tyzzer's disease in a puppy. Vet Pathol. 1995;32:63–65
  36. Iwanaka M, Orita S, Mokuno Y, et al. Tyzzer's disease complicated with distemper in a puppy. J Vet Med Sci. 1993;55:337–339
  37. Whittaker D. Tyzzer's disease in puppies. Vet Rec. 1988;10:238
  38. Cantor GH, Byrne BA, Hines SA, et al. VapA-negative Rhodococcus equi in a dog with necrotizing pyogranulomatous hepatitis, osteomyelitis, and myositis. J Vet Diagn Invest. 1998;10:297–300
  39. Sykes JE, Cannon AB, Norris AJ, et al. Mycobacterium tuberculosis complex infection in a dog. J Vet Intern Med. 2007;21:1108–1112
  40. Hackendahl NC, Mawby DI, Bemis DA, et al. Putative transmission of Mycobacterium tuberculosis infection from a human to a dog. J Am Vet Med Assoc. 2004;225:1573–1577
  41. Barry M, Taylor J, Woods JP. Disseminated Mycobacterium avium infection in a cat. Can Vet J. 2002;43:369–371
  42. Baral RM, Metcalfe SS, Krockenberger MB, et al. Disseminated Mycobacterium avium infection in young cats: overrepresentation of Abyssinian cats. J Feline Med Surg. 2006;8:23–44
  43. Griffin A, Newton AL, Aronson LR, et al. Disseminated Mycobacterium avium complex infection following renal transplantation in a cat. J Am Vet Med Assoc. 2003;222:1097–1101
  44. Gunn-Moore DA, Jenkins PA. Tuberculosis in cats. Vet Rec. 1994;134:336
  45. Jordan HL, Cohn LA, Armstrong PJ. Disseminated Mycobacterium avium complex infection in three Siamese cats. J Am Vet Med Assoc. 1994;204:90–93
  46. O'Toole D, Tharp S, Thomsen BV, et al. Fatal mycobacteriosis with hepatosplenomegaly in a young dog due to Mycobacterium avium. J Vet Diagn Invest. 2005;17:200–204
  47. Zeiss CJ, Jardine J, Huchzermeyer H. A case of disseminated tuberculosis in a dog caused by Mycobacterium avium-intracellulare. J Am Anim Hosp Assoc. 1994;30:419–424
  48. Grooters AM, Couto CG, Andrews JM, et al. Systemic Mycobacterium smegmatis infection in a dog. J Am Vet Med Assoc. 1995;206:200–202
  49. Shackelford CC, Reed WM. Disseminated Mycobacterium avium infection in a dog. J Vet Diagn Invest. 1989;1:273–275
  50. Gow AG, Gow DJ. Disseminated Mycobacterium avium complex infection in a dog. Vet Rec. 2008;162:594–595
  51. Carpenter JL, Myers AM, Conner MW, et al. Tuberculosis in five basset hounds. J Am Vet Med Assoc. 1988;192:1563–1568
  52. Naughton JF, Mealey KL, Wardrop KJ, et al. Systemic Mycobacterium avium infection in a dog diagnosed by polymerase chain reaction analysis of buffy coat. J Am Anim Hosp. 2005;41:128–132
  53. Eggers JS, Parker GA, Braaf HA, et al. Disseminated Mycobacterium avium infection in three miniature schnauzer litter mates. J Vet Diagn Invest. 1997;9:424–427
  54. Appleyard GD, Clark EG. Histologic and genotypic characterization of a novel Mycobacterium species found in three cats. J Clin Microbiol. 2002;40:2425–2430
  55. VanSteenhouse JL, DeNovo RC. Atypical Histoplasma capsulatum infection in a dog. J Am Vet Med Assoc. 1986;188:527–528
  56. Clinkenbeard KD, Cowell RL, Tyler RD. Disseminated histoplasmosis in dogs: 12 cases (1981-1986). J Am Vet Med Assoc. 1988;193:1443–1447
  57. Clinkenbeard KD, Cowell RL, Tyler RD. Disseminated histoplasmosis in cats: 12 cases (1981-1986). J Am Vet Med Assoc. 1987;190:1445–1448
  58. Bruchim Y, Elad D, Klainbart S. Disseminated aspergillosis in two dogs in Israel. Mycoses. 2006;49:130–133
  59. Kelly SE, Shaw SE, Clark WT. Long-term survival of four dogs with disseminated Aspergillus terreus infection treated with itraconazole. Aust Vet J. 1995;72:311–313
  60. Wilson SM, Odeon A. Disseminated Aspergillus terreus infection in a dog. J Am Anim Hosp Assoc. 1992;28:447–450
  61. Dallman MJ, Dew TL, Tobias L, et al. Disseminated aspergillosis in a dog with diskospondylitis and neurologic deficits. J Am Vet Med Assoc. 1992;200:511–513
  62. Wood GL, Hirsh DC, Selcer RR, et al. Disseminated aspergillosis in a dog. J Am Vet Med Assoc. 1978;172:704–707
  63. Robinson WF, Connole MD, King TJ, et al. Systemic mycosis due to Aspergillus deflectus in a dog. Aust Vet J. 2000;78:600–602
  64. Kahler JS, Leach MW, Jang S, et al. Disseminated aspergillosis attributable to Aspergillus deflectus in a springer spaniel. J Am Vet Med Assoc. 1990;197:871–874
  65. Day MJ. Canine disseminated aspergillosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 620–626
  66. Ossent P. Systemic aspergillosis and mucormycosis in 23 cats. Vet Rec. 1987;120:330–333
  67. Day MJ. Feline disseminated aspergillosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 626
  68. Rakich PM, Latimer KS. Altered immune function in a dog with disseminated protothecosis. J Am Vet Med Assoc. 1984;185:681–683
  69. Pressler BM, Gookin JL, Sykes JE, et al. Urinary tract manifestations of protothecosis in dogs. J Vet Intern Med. 2005;19:115–119
  70. Rizzi TE, Cowell RL, Meinkoth JH, et al. More than meets the eye: subretinal aspirate from an acutely blind dog. Vet Clin Pathol. 2006;35:111–113
  71. Cook JR, Tyler DE, Coulter DB, et al. Disseminated protothecosis causing acute blindness and deafness in a dog. J Am Vet Med Assoc. 1984;184:1266–1272
  72. Gaunt SD, McGrath RK, Cox HU. Disseminated protothecosis in a dog. J Am Vet Med Assoc. 1984;185:906–907
  73. Green CE, Rakich PM, Latimer KS. Protothecosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 659–665
  74. Davies C, Troy GC. Deep mycotic infections in cats. J Am Anim Hosp Assoc. 1996;32:380–391
  75. Brodey RS, Roszel JF, Rhodes WH, et al. Disseminated coccidioidomycosis in a dog. J Am Vet Med Assoc. 1970;157:926–933
  76. Schubach TMP, Schubach AO, Cuzzi-Maya T, et al. Pathology of sporotrichosis in 10 cats in Rio de Janeiro. Vet Rec. 2003;152:172–175
  77. Kier AB, Mann PC, Wagner JE. Disseminated sporotrichosis in a cat. J Am Vet Med Assoc. 1979;175:202–204
  78. Nasisse MP, van Ee RT, Wright B. Ocular changes in a cat with disseminated blastomycosis. J Am Vet Med Assoc. 1985;187:629–631
  79. Legendre AM. Blastomycosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 569–576
  80. Collett MG, Doyle AS, Reyers F, et al. Fatal disseminated cryptococcosis and concurrent ehrlichiosis in a dog. J S Afr Vet Assoc. 1987;58:197–202
  81. Watt PR, Robins GM, Galloway AM, et al. Disseminated opportunistic fungal disease in dogs: 10 cases (1982-1990). J Am Vet Med Assoc. 1995;207:67–70
  82. Greene CE. Histoplasmosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 577–583
  83. Malik R, Krockenberger M, O'Brien CR, et al. Cryptococcosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 584–598
  84. Greene RT. Coccidioidomycosis and paracoccidioidomycosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 598–608
  85. Rosser EJ, Dunstan RW. Sporotrichosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 608–612
  86. Rallis T, Day MJ, Saridomichelakis MN, et al. Chronic hepatitis associated with canine leishmaniosis (Leishmania infantum): a clinicopathological study of 26 cases. J Comp Pathol. 2005;132:145–152
  87. Cortadellas O. Initial and long term efficacy of a lipid emulsion of amphotericin B desoxycholate in the management of canine leishmaniasis. J Vet Intern Med. 2003;17:808–812
  88. Baneth G, Harmelin A, Presentey BZ. Hepatozoon canis infection in two dogs. J Am Vet Med Assoc. 1995;206:1891–1894
  89. Panciera RJ, Gatto NT, Crystal MA, et al. Canine hepatozoonosis in Oklahoma. J Am Anim Hosp Assoc. 1997;33:221–225
  90. Baneth G. Hepatozoon canis infection. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 698–704
  91. Baneth G. Feline hepatozoonosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 705
  92. Ewing GO. Granulomatous cholangiohepatitis in a cat due to a protozoan parasite resembling Hepatozoon canis. Feline Pract. 1977;7:37–40
  93. Baneth G, Aroch I, Tal N, et al. Hepatozoon species infection in domestic cats: a retrospective study. Vet Parasitol. 1998;79:123–133
  94. Vincent-Johnson NA, Macintire DK, Lindsay DS, et al. A new Hepatozoon species from dogs: description of the causative agent of canine hepatozoonosis in North America. J Parasitol. 1997;83:1165–1172
  95. Cummings CA, Panciera RJ, Kocan KM, et al. Characterization of stages of Hepatozoon americanum and of parasitized canine host cells. Vet Pathol. 2005;42:788–796
  96. Li Y, Wang C, Allen KE, et al. Diagnosis of canine Hepatozoon spp. infection by quantitative PCR. Vet Parasitol. 2008;157:50–58
  97. Mathew JS, Saliki JT, Ewing SA, et al. An indirect enzyme-linked immunosorbent assay for diagnosis of American canine hepatozoonosis. J Diagn Invest. 2001;13:17–21
  98. Macintire DK, Vincent-Johnson NA, Kane CW, et al. Treatment of dogs infected with Hepatozoon americanum: 53 cases (1989-1998). J Am Vet Med Assoc. 2001;218:77–82
  99. Wasson K, Peper RL. Mammalian microsporidiosis. Vet Pathol. 2000;37:113–128
  100. Szabo JR, Shadduck JA. Experimental encephalitozoonosis in neonatal dogs. Vet Pathol. 1987;24:99–108
  101. Meinkoth J, Kocan AA, Whitworth L, et al. Cats surviving natural infection with Cytauxzoon felis: 18 cases (1997-1998). J Vet Intern Med. 2000;14:521–525
  102. Greene CE, Latimer K, Hopper E, et al. Administration of diminazene aceturate or imidocarb dipropionate for treatment of cytauxzoonosis in cats. J Am Vet Med Assoc. 1999;215:497–500
  103. Dubey JP, Lappin MR. Toxoplasmosis and neosporosis. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 754–774
  104. Dubey JP, Zajac A, Osofsky SA, et al. Acute primary toxoplasmic hepatitis in an adult cat shedding Toxoplasma gondii oocysts. J Am Vet Med Assoc. 1990;197:1616–1618
  105. Henriksen P, Dietz HH, Henriksen SA. Fatal toxoplasmosis in five cats. Vet Parasitol. 1994;55:15–20
  106. Bernstein L, Gregory CR, Aronson LR, et al. Acute toxoplasmosis following renal transplantation in three cats and a dog. J Am Vet Med Assoc. 1999;215:1123–1126
  107. Davidson MG, Rottman JB, English RV, et al. Feline immunodeficiency virus predisposes cats to acute generalized toxoplasmosis. Am J Pathol. 1993;143:1486–1497
  108. Dubey JP, Carpenter JL. Neonatal toxoplasmosis in littermate cats. J Am Vet Med Assoc. 1993;203:1546–1549
  109. Dubey JP, Carpenter JL. Histologically confirmed clinical toxoplasmosis in cats: 100 cases (1952-1990). J Am Vet Med Assoc. 1993;203:1556–1566
  110. Holmberg TA, Vernau W, Melli AC, et al. Neospora caninum associated with septic peritonitis in an adult dog. Vet Clin Pathol. 2006;35:235–238
  111. Dubey JP, Slife LN, Speer CA, et al. Fatal cutaneous and visceral infection in a Rottweiler dog associated with a Sarcocystis-like protozoan. J Vet Diagn Invest. 1991;3:72–75
  112. Robin A, Williams P, Landsdowne J, et al. Fatal hepatic sarcocystosis in a puppy with eosinophilia and eosinophilic peritoneal effusion. Vet Clin Pathol. 2006;35:353–357
  113. Sellon RK. Canine viral diseases. In:  Ettinger SJ,  Feldman EC editor. Textbook of Veterinary Internal Medicine. (ed 6). St Louis: Elsevier; 2005;p. 646–652
  114. Parry HB. Viral hepatitis of dogs (Rubarth's disease). Vet Rec. 1950;38:559–565
  115. Pay TWF. Infectious canine hepatitis (Hepatitis contagiosa canis[Rubarth]). Vet Rec. 1950;62:551–558
  116. Chouinard L, Martineau D, Forget C, et al. Use of polymerase chain reaction and immunohistochemistry for detection of canine adenovirus type 1 in formalin-fixed, paraffin-embedded liver of dogs with chronic hepatitis or cirrhosis. J Vet Diagn. 1998;10:320–325
  117. Jarrett WF, O'Neil BW. A new transmissible agent causing acute hepatitis, chronic hepatitis, and cirrhosis in dogs. Vet Rec. 1985;116:625–629
  118. Jarrett WFH, O'Neil BW, Lindholm I. Persistent hepatitis and chronic fibrosis induced by canine acidophil cell hepatitis virus. Vet Rec. 1987;120:234–235
  119. Green CE, Carmichael LE. Canine herpesvirus. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 47–53
  120. Reinacher M, Theilen G. Frequency and significance of feline leukemia virus infection in necropsied cats. Am J Vet Res. 1987;48:939–945
  121. Foley JE. Feline infectious peritonitis and feline enteric coronavirus. In:  Greene CE editors. Infectious Diseases of the Dog and Cat. (ed 3). St Louis: Elsevier; 2006;p. 663–666
  122. Gibson C, Parry N. Feline infectious peritonitis: typical findings and a new PCR test. Vet Med. 2007;102:375–379
  123. Ishida T, Shibanai A, Tanaka S, et al. Use of recombinant feline interferon and glucocorticoid in the treatment of feline infectious peritonitis. J Feline Med Surg. 2004;6:107–109
  124. Ritz S, Egberink H, Hartmann K. Effect of feline interferon-omega on the survival time and quality of life of cats with feline infectious peritonitis. J Vet Intern Med. 2007;21:1193–1197
  125. Dumlar JS, Bakken JS. Ehrlichial diseases of humans: emerging tickborne infections. Clin Infect Dis. 1995;20:1102–1110
  126. Hu LT, Klempner MS. Host-pathogen interactions in the immunopathogenesis of Lyme disease. J Clin Immunol. 1997;17:354–365
  127. Thornbrugh JM, Edwards NJ, Jordan HE. Metametorchis infection in a domestic cat. J Am Anim Hosp Assoc. 1990;26:494–495
  128. Haney DR, Christiansen JS, Toll J. Severe cholestatic liver disease secondary to liver fluke (Platynosomum concinnum). J Am Anim Hosp. 2006;42:234–237

PII: S1938-9736(09)00072-5

doi: 10.1053/j.tcam.2009.06.004

Topics in Companion Animal Medicine
Volume 24, Issue 4 , Pages 189-198 , November 2009