Topics in Companion Animal Medicine
Volume 24, Issue 3 , Pages 144-150 , August 2009

Molecular Diagnostics of Hematologic Malignancies

  • Anne Avery, VMD, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to: Anne Avery, VMD, PhD, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523

References 

  1. Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346:1937–1947
  2. Morley A. Quantifying leukemia. N Engl J Med. 1998;339:627–629
  3. London CA, Galli SJ, Yuuki T, et al. Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit. Exp Hematol. 1999;27:689–697
  4. Ma Y, et al. Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms. J Invest Dermatol. 1999;112:165–170
  5. Webster JD, et al. The role of c-KIT in tumorigenesis: evaluation in canine cutaneous mast cell tumors. Neoplasia. 2006;8:104–111
  6. Webster JD, et al. Evaluation of prognostic markers for canine mast cell tumors treated with vinblastine and prednisone. BMC Vet Res. 2008;4:32
  7. Simoes JP, Schoning P, Butine M. Prognosis of canine mast cell tumors: a comparison of three methods. Vet Pathol. 1994;31:637–647
  8. Romansik EM, et al. Mitotic index is predictive for survival for canine cutaneous mast cell tumors. Vet Pathol. 2007;44:335–341
  9. Scase TJ, et al. Canine mast cell tumors: correlation of apoptosis and proliferation markers with prognosis. J Vet Intern Med. 2006;20:151–158
  10. Zavodovskaya R, Chien MB, London CA. Use of kit internal tandem duplications to establish mast cell tumor clonality in 2 dogs. J Vet Intern Med. 2004;18:915–917
  11. Wong S, Witte ON. The BCR-ABL story: bench to bedside and back. Annu Rev Immunol. 2004;22:247–306
  12. In:  Beutler B, et al. editor. Williams Hematology. (ed 6). McGraw-Hill; 2001;p. 1085–1124
  13. Hughes TP, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. [see comment] N Engl J Med. 2003;349:1423–1432
  14. Breen M, Modiano JF. Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans—man and his best friend share more than companionship. Chromosome Res. 2008;16:145–154
  15. Edry E, Melamed D. Class switch recombination: a friend and a foe. Clin Immunol. 2007;123:244–251
  16. Bench AJ, et al. Molecular genetic analysis of haematological malignancies II: Mature lymphoid neoplasms. Int J Lab Hematol. 2007;29:229–260
  17. Thomas R, et al. Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes. Br J Cancer. 2003;89:1530–1537
  18. Delves PJ, Roitt IM. The immune system (First of two parts). N Engl J Med. 2000;343:37–49
  19. Blom B, Spits H. Development of human lymphoid cells. Annu Rev Immunol. 2006;24:287–320
  20. Swerdlow SH. Genetic and molecular genetic studies in the diagnosis of atypical lymphoid hyperplasias versus lymphoma. Hum Pathol. 2003;34:346–351
  21. Vernau W, Moore PF. An immunophenotypic study of canine leukemias and preliminary assessment of clonality by polymerase chain reaction. Vet Immunol Immunopathol. 1999;69:145–164
  22. Burnett RC, et al. Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes. Vet Pathol. 2003;40:32–41
  23. Tamura K, et al. Development of the polymerase chain reaction assay based on the canine genome database for detection of monoclonality in B cell lymphoma. Vet Immunol Immunopathol. 2006;110:163–167
  24. Yagihara H, et al. Genomic organization of the T-cell receptor γ gene and PCR detection of its clonal rearrangement in canine T-cell lymphoma/leukemia. Vet Immunol Immunopathol. 2007;115:375–382
  25. Burnett RC, et al. Evolution of a B-cell lymphoma to multiple myeloma after chemotherapy. J Vet Intern Med. 2004;18:768–771
  26. Keller RL, et al. Detection of neoplastic lymphocytes in peripheral blood of dogs with lymphoma by polymerase chain reaction for antigen receptor gene rearrangement. Vet Clin Pathol. 2004;33:145–149
  27. Yamazaki J, et al. Quantitative assessment of minimal residual disease (MRD) in canine lymphoma by using real-time polymerase chain reaction. Vet Immunol Immunopathol. 2008;126:321–331
  28. van Dongen JJ, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17:2257–2317
  29. Zucca E, et al. Molecular analysis of the progression from Helicobacter pylori-associated chronic gastritis to mucosa-associated lymphoid-tissue lymphoma of the stomach. N Engl J Med. 1998;338:804–810
  30. Flory AB, et al. Stage migration in dogs with lymphoma. J Vet Intern Med. 2007;21:1041–1047
  31. Moore PF, et al. Characterization of feline T cell receptor gamma (TCRG) variable region genes for the molecular diagnosis of feline intestinal T cell lymphoma. Vet Immunol Immunopathol. 2005;106:167–178
  32. Werner JA, et al. Characterization of feline immunoglobulin heavy chain variable region genes for the molecular diagnosis of B-cell neoplasia. Vet Pathol. 2005;42:596–607
  33. Weiss AT, et al. Characterization of C-, J- and V-region-genes of the feline T-cell receptor gamma. Vet Immunol Immunopathol. 2008;124:63–74
  34. Carter JE, et al. Erythrophagocytic low-grade extranodal T-cell lymphoma in a cat. Vet Clin Pathol. 2008;37:416–421

PII: S1938-9736(09)00021-X

doi: 10.1053/j.tcam.2009.03.005

Topics in Companion Animal Medicine
Volume 24, Issue 3 , Pages 144-150 , August 2009