Topics in Companion Animal Medicine
Volume 24, Issue 3 , Pages 157-162 , August 2009

Lymphoma: Which Chemotherapy Protocol and Why?

  • Ruthanne Chun, DVM, Dipl. ACVIM (Oncology)

      Affiliations

    • Corresponding Author InformationAddress reprint requests to: Ruthanne Chun, DVM, Dipl. ACVIM (Oncology), University of Wisconsin–Madison School of Veterinary Medicine, 2015 Linden Dr, Madison, WI 53706

References 

  1. Vail D, Young KM. Hematopoietic tumors. In:  Vail D,  Withrow S editor. Withrow & MacEwen's Small Animal Clinical Oncology. (ed 4). St Louis: Saunders Elsevier; 2007;p. 699–733
  2. Carter RF, Harris CK, Withrow SJ, et al. Chemotherapy of canine lymphoma with histopathological correlation: doxorubicin alone compared to COP as first treatment regimen. J Am Anim Hosp Assoc. 1987;23:587–596
  3. Valerius KD, Ogilvie GK, Mallinckrodt CH, et al. Doxorubicin alone or in combination with asparaginase, followed by cyclophosphamide, vincristine, and prednisone for treatment of multicentric lymphoma in dogs: 121 cases (1987-1995). J Am Vet Med Assoc. 1997;210:512–516
  4. Postorino N, Susaneck S, Withrow S. Single agent therapy with Adriamycin for canine lymphosarcoma. J Am Anim Hosp Assoc. 1989;25:221–225
  5. Simon D, Moreno SN, Hirschberger J, et al. Efficacy of a continuous, multiagent chemotherapeutic protocol versus a short-term single-agent protocol in dogs with lymphoma. J Am Vet Med Assoc. 2008;232:879–885
  6. Imondi AR, Della Torre P, Mazue G, et al. Dose-response relationship of dexrazoxane for prevention of doxorubicin-induced cardiotoxicity in mice, rats, and dogs. Cancer Res. 1996;56:4200–4204
  7. Langer SW, Sehested M, Jensen PB. Treatment of anthracycline extravasation with dexrazoxane. Clin Cancer Res. 2000;6:3680–3686
  8. Mahoney JA, Bergman PJ, Camps-Palau MA, et al. Treatment of doxorubicin extravasation with intravenous dexrazoxane in a cat. J Vet Intern Med. 2007;21:872–873
  9. Sauerbrey ML, Mullins MN, Bannink EO, et al. Lomustine and prednisone as a first-line treatment for dogs with multicentric lymphoma: 17 cases (2004-2005). J Am Vet Med Assoc. 2007;230:1866–1869
  10. Kristal O, Rassnick KM, Gliatto JM, et al. Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs. J Vet Intern Med. 2004;18:75–80
  11. Moore AS, London CA, Wood CA, et al. Lomustine (CCNU) for the treatment of resistant lymphoma in dogs. [see comments] J Vet Intern Med. 1999;13:395–398
  12. Saba CF, Thamm DH, Vail DM. Combination chemotherapy with l-asparaginase, lomustine, and prednisone for relapsed or refractory canine lymphoma. J Vet Intern Med. 2007;21:127–132
  13. Stone MS, Goldstein MA, Cotter SM. Comparison of two protocols for induction of remission in dogs with lymphoma. J Am Anim Hosp Assoc. 1991;27:315–321
  14. Cotter SM. Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone: I. treatment of dogs. J Am Anim Hosp Assoc. 1983;19:159–165
  15. Cotter SM, Goldstein MA. Comparison of two protocols for maintenance of remission in dogs with lymphoma. J Am Anim Hosp Assoc. 1987;23:495–499
  16. Jeffreys AB, Knapp DW, Carlton WW, et al. Influence of asparaginase on a combination chemotherapy protocol for canine multicentric lymphoma. J Am Anim Hosp Assoc. 2005;41:221–226
  17. Baskin CR, Couto CG, Wittum TE. Factors influencing first remission and survival in 145 dogs with lymphoma: a retrospective study. J Am Anim Hosp Assoc. 2000;36:404–409
  18. Garrett LD, Thamm DH, Chun R, et al. Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma. J Vet Intern Med. 2002;16:704–709
  19. Hosoya K, Kisseberth WC, Lord LK, et al. Comparison of COAP and UW-19 protocols for dogs with multicentric lymphoma. J Vet Intern Med. 2007;21:1355–1363
  20. Zemann BI, Moore AS, Rand WM, et al. A combination chemotherapy protocol (VELCAP-L) for dogs with lymphoma. J Vet Intern Med. 1998;12:465–470
  21. Moore AS, Cotter SM, Rand WM, et al. Evaluation of a discontinuous treatment protocol (VELCAP-S) for canine lymphoma. J Vet Intern Med. 2001;15:348–354
  22. Keller ET, MacEwen EG, Rosenthal RC, et al. Evaluation of prognostic factors and sequential combination chemotherapy with doxorubicin for canine lymphoma. J Vet Intern Med. 1993;7:289–295
  23. Myers NC, Moore AS, Rand WM, et al. Evaluation of a multidrug chemotherapy protocol (ACOPA II) in dogs with lymphoma. J Vet Intern Med. 1997;11:333–339
  24. MacDonald VS, Thamm DH, Kurzman ID, et al. Does l-asparaginase influence efficacy or toxicity when added to a standard CHOP protocol for dogs with lymphoma?. J Vet Intern Med. 2005;19:732–736
  25. Monahan B, Allegra C. Antifolates. In:  Chabner B,  Longo D editor. Cancer Chemotherapy and Biotherapy Principles and Practice. Philadelphia: Lippincott Williams & Wilkins; 2006;p. 91–124
  26. Charney SC, Bergman PJ, Hohenhaus AE, et al. Risk factors for sterile hemorrhagic cystitis in dogs with lymphoma receiving cyclophosphamide with or without concurrent administration of furosemide: 216 cases (1990-1996). J Am Vet Med Assoc. 2003;222:1388–1393
  27. Chun R, Garrett LD, Vail DM. Evaluation of a high-dose chemotherapy protocol with no maintenance therapy for dogs with lymphoma. J Vet Intern Med. 2000;14:120–124
  28. Northrup NC, Rassnick KM, Snyder LA, et al. Neutropenia associated with vincristine and l-asparaginase induction chemotherapy for canine lymphoma. J Vet Intern Med. 2002;16:570–575
  29. McCaw DL, Miller MA, Bergman PJ, et al. Vincristine therapy for mast cell tumors in dogs. J Vet Intern Med. 1997;11:375–378
  30. Golden DL, Langston VC. Uses of vincristine and vinblastine in dogs and cats. J Am Vet Med Assoc. 1988;193:1114–1117
  31. Morrison-Collister KE, Rassnick KE, Northrup NC. A combination chemotherapy protocol with MOPP and CCNU consolidation (Tufts VELCAP-SC) for the treatment of canine lymphoma. Vet Comp Oncol. 2003;1:180–190
  32. Rassnick KM, McEntee MC, Erb HN, et al. Comparison of 3 protocols for treatment after induction of remission in dogs with lymphoma. J Vet Intern Med. 2007;21:1364–1373
  33. Meleo KA. The role of radiotherapy in the treatment of lymphoma and thymoma. Vet Clin North Am Small Anim Pract. 1997;27:115–129
  34. Williams LE, Johnson JL, Hauck ML, et al. Chemotherapy followed by half-body radiation therapy for canine lymphoma. J Vet Intern Med. 2004;18:703–709
  35. Laing EJ, Fitzpatrick PJ, Binnington AG, et al. Half-body radiotherapy in the treatment of canine lymphoma. J Vet Intern Med. 1989;3:102–108
  36. Storb R, Epstein RB, Ragde H, et al. Marrow engraftment by allogeneic leukocytes in lethally irradiated dogs. Blood. 1967;30:805–811
  37. Abrams-Ogg AC, Kruth SA, Carter RF, et al. Clinical and pathological findings in dogs following supralethal total body irradiation with and without infusion of autologous long-term marrow culture cells. Can J Vet Res. 1993;57:79–88
  38. Appelbaum FR, Deeg HJ, Storb R, et al. Marrow transplant studies in dogs with malignant lymphoma. Transplantation. 1985;39:499–504
  39. Bowles CA, Lucas D. Clinical and immunological response of lymphoma dogs following chemotherapy and irradiation. Comp Immunol Microbiol Infect Dis. 1980;3:317–326
  40. Deeg HJ, Appelbaum FR, Weiden PL, et al. Autologous marrow transplantation as consolidation therapy for canine lymphoma: efficacy and toxicity of various regimens of total body irradiation. Am J Vet Res. 1985;46:2016–2018
  41. Weiden PL, Storb R, Deeg HJ, et al. Total body irradiation and autologous marrow transplantation as consolidation therapy for spontaneous canine lymphoma in remission. Exp Hematol. 1979;7(Suppl 5):160–163
  42. Weiden PL, Storb R, Deeg HJ, et al. Prolonged disease-free survival in dogs with lymphoma after total-body irradiation and autologous marrow transplantation consolidation of combination-chemotherapy-induced remissions. Blood. 1979;54:1039–1049
  43. Weiden PL, Storb R, Lerner KG, et al. Treatment of canine malignancies by 1200 R total body irradiation and autologous marrow grafts. Exp Hematol. 1975;3:124–134
  44. Weiden PL, Storb R, Sale GE, et al. Allogeneic hematopoietic grafts after total-body irradiation in dogs with spontaneous tumors. J Natl Cancer Inst. 1978;61:353–357
  45. Frimberger AE, Moore AS, Rassnick KM, et al. A combination chemotherapy protocol with dose intensification and autologous bone marrow transplant (VELCAP-HDC) for canine lymphoma. J Vet Intern Med. 2006;20:355–364
  46. Legendre AM. Treatment of dogs with lymphoma: a work in progress. J Vet Intern Med. 2007;21:1166–1167

PII: S1938-9736(09)00019-1

doi: 10.1053/j.tcam.2009.03.003

Topics in Companion Animal Medicine
Volume 24, Issue 3 , Pages 157-162 , August 2009

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